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Maturitas 36 : 49—61, As mentioned earlier, studies of vastus lateralis biopsies show fiber-type CSA to be larger in men than in women. J Clin Invest 81 : —, For instance, hypogondal and eugonadal men exhibit similar limb muscle strength and endurance during exercise Analysis of contractile function in OVX mice reveals a significant decrease in maximal isometric tetanic force from sham levels mN to mN 67 , This could be due to minute changes in fiber-type contribution, CSA, or changes in calcium-handling proteins.

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In the studies referenced in the previous sections, there is no change in MyHC isoform expression or overall muscle fiber-type composition, but there are estrogen-related changes in fiber-type diameter, muscle size, contractility, and the actin-myosin interaction.

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More specifically, women fatigue similarly in both muscles, whereas men fatigue more in the lumbar musculature compared with the biceps femoris Table 2 Fiber-type expression and area. Separating the rabbit masseter into 10 different muscle compartments reveals that two of the compartments consist of more type-IIA fibers in young males vs. Influence of testosterone on muscle fiber type and morphology. Men supplemented with 17beta-estradiol have increased beta-oxidation capacity in skeletal muscle. Thyroid hormones differentially affect sarcoplasmic reticulum function in rat atria and ventricles. Additionally, all of the fibers measured in men have significantly larger cross-sectional areas CSA compared with women as normalized to biopsy section area

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